NBK said:There is a lot of confusion here. I would worry more about shot placement than caliber. All of the above calibers will smash North American game if used correctly with the right bullets.
I have seen truck loads of elk (literally) go down with various calibers etc. Big heavy flat shooting calibers wound animals just like lighter calibers. Most folks should not be taking long shots anyways. It takes practice and knowledge. Yup, ya' get lucky now and then. But it is just that. I have become more fond of calibers with less recoil as of late and have not noticed any lack of performance regarding the end result!
Just my in field observations...
In that case I'll take my 22-250 35gr out ;D